2004plus introduces several new bosses as well as enhancing existing ones

  * [[Barrows]]
  * [[Empress Dryad]]
  * [[Gnome-champion-solo|Gnome Champion (solo)]]
  * [[Gnome-champion-multi|Gnome Champion (multi)]]
  * [[Infernal Demon]]
  * [[Kraken]]
  * [[Nightmare Zone (Nightmare Mode)]]
  * [[Scurrius]]
  * [[Ursinae]]
  * [[Zulrah]]